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39 , 40 The interaction between MM cells and the BM microenvironment leads to considerable secretion of cytokines and growth factors, including IL‐6, insulin‐like growth factor (IGF‐1), B‐cell activating factor (BAFF), a proliferation‐inducing ligand (APRIL), tumor necrosis factor‐α (TNF‐α), and vascular endothelial growth factor (VEGF)